Improved Manufacturing Process for Pyronaridine Tetraphosphate


Dong Won Lee, Seung Kyu Lee, Jun Ho Cho, Seung Soo Yoon, Journal of Information Processing Systems Vol. 35, No. 2, pp. 521-524, Feb. 2014  

https://doi.org/10.5012/bkcs.2014.35.2.521
Keywords: Antimalarial agent, Pyronaridine tetraphosphate, Manufacturing process
Fulltext:

Abstract

Pyronaridine tetraphosphate (1) is a well-known antimalarial drug. However, it required a carefully optimized production process for the manufacture of pyronaridine tetraphosphate. Each step of its manufacturing process was reinvestigated. For the cyclization of 4-chloro-2-(6-methoxy-pyridin-3-yl-amino)-benzoic acid 6 to 7,10- dichloro-2-methoxybenzo[b]-1,5-naphthyridine 5, an improved process was developed to eliminated critical process impurity (BIA). By the redesign of the formation of triphosphate salt, the purity as API grade was increased. Thus, a robust manufacturing process with an acceptable process performance has been developed to produce high quality pyronaridine tetraphosphate.


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Cite this article
[APA Style]
Lee, D., Lee, S., Cho, J., & Yoon, S. (2014). Improved Manufacturing Process for Pyronaridine Tetraphosphate. Bulletin of the Korean Chemical Society, 35(2), 521-524. DOI: 10.5012/bkcs.2014.35.2.521.

[IEEE Style]
D. W. Lee, S. K. Lee, J. H. Cho, S. S. Yoon, "Improved Manufacturing Process for Pyronaridine Tetraphosphate," Bulletin of the Korean Chemical Society, vol. 35, no. 2, pp. 521-524, 2014. DOI: 10.5012/bkcs.2014.35.2.521.

[ACM Style]
Dong Won Lee, Seung Kyu Lee, Jun Ho Cho, and Seung Soo Yoon. 2014. Improved Manufacturing Process for Pyronaridine Tetraphosphate. Bulletin of the Korean Chemical Society, 35, 2, (2014), 521-524. DOI: 10.5012/bkcs.2014.35.2.521.